Mutational analysis of the candidate tumor suppressor gene ING1 in Indian oral squamous cell carcinoma

被引：26

作者：

Krishnamurthy, J

Kannan, K

Feng, J

Mohanprasad, BKC

Tsuchida, N

Shanmugam, G ^{[1
]}

机构：

[1] Madurai Kamaraj Univ, Sch Biol Sci, Div Canc Biol, Madurai 625021, Tamil Nadu, India

[2] Tokyo Med & Dent Univ, Dept Mol Cellular Oncol & Microbiol, Bunkyo Ku, Tokyo 113, Japan

[3] Govt Rajaji Hosp, Surg Oncol Unit, Madurai 625002, Tamil Nadu, India

来源：

ORAL ONCOLOGY | 2001年 / 37卷 / 03期

关键词：

ING1; gene; mutation; oral cancer; single strand conformation polymorphism;

D O I：

10.1016/S1368-8375(00)00081-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

INGI, a recently identified candidate tumor suppressor gene, involved in the p53 signaling pathway is mapped at chromosome 13q34. Since loss of heterozygosity at 13q34 has been reported in squamous cell carcinoma of head and neck, we screened for mutations in INGI by polymerase chain reaction-single strand conformation polymorphism in 71 oral squamous cell carcinomas (OSCC) from India, 15 of which were known to harbor pn mutations. A single polymorphism (G to A) was detected in 14 (19.7%) of the tumors analyzed. No mutation was observed in any of the 71 OSCCs analyzed. These results suggest that INGI is not a target for mutational inactivation in OSCC of Indians. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：222 / 224

页数：3

共 20 条

[1] Suppression of the novel growth inhibitor p33(ING1) promotes neoplastic transformation [J].