Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes

被引：205

作者：

Aguayo-Mazzucato, Cristina ^{[1
]}

Bonner-Weir, Susan ^{[1
]}

机构：

[1] Harvard Med Sch, Harvard Stem Cell Inst, Joslin Diabet Ctr, Boston, MA 02215 USA

来源：

CELL METABOLISM | 2018年 / 27卷 / 01期

关键词：

60-PERCENT PARTIAL-PANCREATECTOMY; IMPAIRED GLUCOSE-TOLERANCE; ADULT-MOUSE PANCREAS; IN-VITRO; PROGENITOR CELLS; ENDOCRINE PANCREAS; HUMAN ISLETS; DUCT CELLS; EXOCRINE PANCREAS; 90-PERCENT PANCREATECTOMY;

D O I：

10.1016/j.cmet.2017.08.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Diabetes is the result of having inadequate supply of functional insulin-producing b cells. Two possible approaches for replenishing the beta cells are: (1) replacement by transplanting cadaveric islets or beta cells derived from human embryonic stem cells/induced pluripotent stem cells and (2) induction of endogenous regeneration. This review focuses on endogenous regeneration, which can follow two pathways: enhanced replication of existing beta cells and formation of new beta cells from cells not expressing insulin, either by conversion from a differentiated cell type (transdifferentiation) or differentiation from progenitors (neogenesis). Exciting progress on both pathways suggest that regeneration may have therapeutic promise.

引用

页码：57 / 67

页数：11

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