Simple chemoenzymatic access to enantiopure pharmacologically interesting (R)-2-hydroxypropiophenones

被引：34

作者：

Demir, AS ^{[1
]}

Hamamci, H

Sesenoglu, O

Aydogan, F

Capanoglu, D

Neslihanoglu, R

机构：

[1] Middle E Tech Univ, Dept Chem, TR-06531 Ankara, Turkey

[2] Middle E Tech Univ, Dept Biotechnol, TR-06531 Ankara, Turkey

[3] Middle E Tech Univ, Dept Food Engn, TR-06531 Ankara, Turkey

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 13期

关键词：

D O I：

10.1016/S0957-4166(01)00346-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A chemoenzymatic synthesis of pharmacological interesting (R)-2-hydroxypropiophenones starting from propiophenone derivatives is described. Manganese(III) acetate-mediated acetoxylation followed by fungus-mediated hydrolysis of propiophenone derivatives affords (R)-2-hydroxypropiophenones in high enantiomeric excess. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1953 / 1956

页数：4

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