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The unique, complex organization of the transcriptionally silent sperm chromatin

被引：72
作者：
Ward, WS
Zalensky, AO
机构：
[1] UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DIV UROL,NEW BRUNSWICK,NJ
[2] UNIV CALIF DAVIS,DEPT BIOL CHEM,DAVIS,CA 95616
来源：
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION | 1996年 / 6卷 / 2-3期
关键词：
sperm chromatin; sperm nucleus; DNA structure;
D O I：
10.1615/CritRevEukarGeneExpr.v6.i2-3.30
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The sperm nucleus contains one haploid copy of the genome that is completely transcriptionally silent and is not being replicated. Recent evidence has revealed that this ''silent'' chromatin nevertheless contains a complex organization at all levels. This includes DNA loop domain formation by the sperm nuclear matrix that is gene specific and highly ordered folding patterns of the chromosomes, particularly with respect to centromere and telomere positioning. Such specificity in the sperm DNA organization suggests functional requirements for their existence. As these begin to emerge, the sperm nucleus is becoming an important model for the study of the eukaryotic genome.
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收藏
页码：139 / 147
页数：9
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