Corticotropin-releasing factor receptor type 1 mediates emotional stress-induced inhibition of food intake and behavioral changes in rats

被引：101

作者：

Hotta, M

Shibasaki, T

Arai, K

Demura, H

机构：

[1] Tokyo Womens Med Univ, Inst Clin Endocrinol, Dept Med, Sch Med,Shinjuku Ku, Tokyo 1628666, Japan

[2] Nippon Med Sch, Dept Physiol, Bunkyo Ku, Tokyo 1138602, Japan

来源：

BRAIN RESEARCH | 1999年 / 823卷 / 1-2期

关键词：

emotional stress; communication box; corticotropin-releasing factor; corticotropin-releasing factor receptor antagonist; feeding behavior; locomotor activity;

D O I：

10.1016/S0006-8993(99)01177-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated whether corticotropin-releasing factor (CRF) receptor type I (CRFR1) is involved in emotional stress-induced inhibition of food intake and behavioral changes in rats. The inhibition of food intake and increase in locomotor activity induced by emotional stress using a communication box were reversed by both intracerebroventricular injection of alpha-helical CRF (9-41), a non-selective CRF receptor antagonist, and intraperitoneal injection of a selective non-peptidic CRFR1 antagonist. These results suggest that CRFR1 mediates at least in part the emotional stress-induced inhibition of feeding behavior and increase in locomotor activity. (C) 1999 Elsevier Science B.V. AU rights reserved.

引用

页码：221 / 225

页数：5

共 39 条

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