Non-peptidic corticotropin-releasing hormone receptor type 1 antagonist reverses restraint stress-induced shortening of sodium pentobarbital-induced sleeping time of rats: evidence that an increase in arousal induced by stress is mediated through CRH receptor type 1

被引：24

作者：

Arai, K ^{[1
]}

Ohata, H ^{[1
]}

Shibasaki, T ^{[1
]}

机构：

[1] Nippon Med Sch, Dept Physiol, Bunkyo Ku, Tokyo 113, Japan

来源：

NEUROSCIENCE LETTERS | 1998年 / 255卷 / 02期

关键词：

corticotropin-releasing hormone; arousal; sodium pentobarbital-induced sleeping time; restraint; CRH receptor type 1; non-peptidic CRH receptor antagonist;

D O I：

10.1016/S0304-3940(98)00719-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stress shortens sodium pentobarbital (PbNa)-induced sleeping time through corticotropin-releasing hormone (CRH) in rats. We investigated whether this effect of brain CRH is mediated by CRH receptor type 1 (CRHR1) using a non-peptidic CRHR1 antagonist in rats. A 60 min period of restraint significantly shortened PbNa-induced sleeping time. This shortening was completely reversed by peripheral administration of CRHR1 antagonist. These results suggest that the stress-induced increase in arousal is mediated by CRHR1. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：103 / 106

页数：4

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