The role of TEL fusion genes in pediatric leukemias

被引：94

作者：

Rubnitz, JE

Pui, CH

Downing, JR

机构：

[1] St Jude Childrens Res Hosp, Dept Hematol Oncol, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Pathol & Lab Med, Memphis, TN 38105 USA

[3] St Jude Childrens Res Hosp, Dept Tumor Cell Biol, Memphis, TN 38105 USA

[4] Univ Tennessee, Coll Med, Dept Pediat, Memphis, TN USA

[5] Univ Tennessee, Coll Med, Dept Pathol, Memphis, TN USA

来源：

LEUKEMIA | 1999年 / 13卷 / 01期

关键词：

TEL; AML1; leukemia; childhood;

D O I：

10.1038/sj.leu.2401258

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The TEL and AML1 genes are common targets of chromosomal translocations in hematopoietic malignancies. The TEL-AML1 fusion gene, created by the t(12;21), is the most common genetic alteration in childhood acute lymphoblastic leukemia and is associated with a favorable outcome. This review summarizes the roles of the TEL and AML1 proteins in hematopoiesis, the potential transforming mechanisms of TEL fusion proteins, and the clinical significance of the TEL-AML1 fusion.

引用

页码：6 / 13

页数：8

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