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The role of TEL fusion genes in pediatric leukemias

被引：94
作者：
Rubnitz, JE
Pui, CH
Downing, JR
机构：
[1] St Jude Childrens Res Hosp, Dept Hematol Oncol, Memphis, TN 38105 USA
[2] St Jude Childrens Res Hosp, Dept Pathol & Lab Med, Memphis, TN 38105 USA
[3] St Jude Childrens Res Hosp, Dept Tumor Cell Biol, Memphis, TN 38105 USA
[4] Univ Tennessee, Coll Med, Dept Pediat, Memphis, TN USA
[5] Univ Tennessee, Coll Med, Dept Pathol, Memphis, TN USA
来源：
LEUKEMIA | 1999年 / 13卷 / 01期
关键词：
TEL; AML1; leukemia; childhood;
D O I：
10.1038/sj.leu.2401258
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The TEL and AML1 genes are common targets of chromosomal translocations in hematopoietic malignancies. The TEL-AML1 fusion gene, created by the t(12;21), is the most common genetic alteration in childhood acute lymphoblastic leukemia and is associated with a favorable outcome. This review summarizes the roles of the TEL and AML1 proteins in hematopoiesis, the potential transforming mechanisms of TEL fusion proteins, and the clinical significance of the TEL-AML1 fusion.
引用
收藏
页码：6 / 13
页数：8
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