Actin in the endocytic pathway: From yeast to mammals

被引：76

作者：

Girao, Henrique ^{[1
]}

Geli, Maria-Isabel ^{[1
]}

Idrissi, Fatima-Zahra ^{[1
]}

机构：

[1] CSIC, IBMB, PCB, E-08028 Barcelona, Spain

来源：

FEBS LETTERS | 2008年 / 582卷 / 14期

关键词：

actin; myosin; Arp2/3; formin; endocytosis; yeast;

D O I：

10.1016/j.febslet.2008.04.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic analysis of endocytosis in yeast early pointed to the essential role of actin in the uptake step. Efforts to identify the machinery involved demonstrated the important contribution of Arp2/3 and the myosins-I. Analysis of the process using live-cell fluorescence microscopy and electron microscopy have recently contributed to refine molecular models explaining clathrin and actin-dependent endocytic uptake. Increasing evidence now also indicates that actin plays important roles in post-internalization events along the endocytic pathway in yeast, including transport of vesicles, motility of endosomes and vacuole fusion. This review describes the present knowledge state on the roles of actin in endocytosis in yeast and points to similarities and differences with analogous processes in mammals. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2112 / 2119

页数：8

共 110 条

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