Cytotoxic activity and effect on nitric oxide production of tirucallane-type triterpenes

被引：30

作者：

Chávez, IO ^{[1
]}

Apan, TR ^{[1
]}

Martínez-Vázquez, M ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 2005年 / 57卷 / 09期

关键词：

D O I：

10.1211/jpp.57.9.0003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hexane extract from the bark of Amphipterygium adstringens, as well as its principal constituents, masticadienonic acid (1) and 3 alpha-hydroxymasticadienolic acid (2), inhibited the growth of five human cancer cell lines. Derivatives of 1, namely 24,255-dihydromasticadienonic acid (3) and masticadienolic acid (4), were also evaluated. The results showed that both 3 and 4 had greater activity than 1 on colon cancer cell lines. The effects of 1-4 on the production of nitric oxide (NO) from both resting and lipopolysaccharide-activated macrophages were determined. it was found that 1, 2 and 4 caused an increase in NO release from resting macrophages; in lipopolysaccharide-activated macrophages, only 2 and 4 caused an increase in NO production.

引用

页码：1087 / 1091

页数：5

共 26 条

[1]

ARGUMEDO DR, 2003, REV SOC QUIM MEX, V47, P167

[2]

Arrieta J, 2003, PLANTA MED, V69, P905, DOI 10.1055/s-2003-45098

[3] TRITERPENOIDS .22. THE CONSTITUTION AND STEREOCHEMISTRY OF MASTICADIENONIC ACID [J].

BARTON, DHR ;

SEOANE, E .

JOURNAL OF THE CHEMICAL SOCIETY, 1956, (NOV) :4150-4157

[4] Antimicrobial and anti-inflammatory activity of folklore:: Mallotus peltatus leaf extract [J].

Chattopadhyay, D ;

Arunachalam, G ;

Mandal, AB ;

Sur, TK ;

Mandal, SC ;

Bhattacharya, SK .

JOURNAL OF ETHNOPHARMACOLOGY, 2002, 82 (2-3) :229-237

[5] Novel effects of nitric oxide [J].

Davis, KL ;

Martin, E ;

Turko, IV ;

Murad, F .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2001, 41 :203-236

[6]

DELRAYO CM, 2000, PLANTA MED, V66, P463

[7] The Griess assay: Suitable for a bio-guided fractionation of anti-inflammatory plant extracts? [J].

Dirsch, VM ;

Stuppner, H ;

Vollmar, AM .

PLANTA MEDICA, 1998, 64 (05) :423-426

[8] (+)-rhododendrol and epi-rhododendrin suppress the NO production by activated macrophages in vivo [J].

Fushiya, S ;

Kabe, Y ;

Ikegaya, Y ;

Takano, F .

PLANTA MEDICA, 1998, 64 (07) :598-602

[9] Tirucallane-type triterpenes from Juliania adstringens [J].

Makino, M ;

Motegi, T ;

Fujimoto, Y .

PHYTOCHEMISTRY, 2004, 65 (07) :891-896

[10] Synthesis of novel furo, thieno, and benzazetoazepines and evaluation of their cytotoxicity [J].

Martínez, LR ;

Zarraga, JGA ;

Duran, ME ;

Apam, MTR ;

Cañas, R .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (12) :1675-1677

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