Synthesis of novel furo, thieno, and benzazetoazepines and evaluation of their cytotoxicity

被引：22

作者：

Martínez, LR

Zarraga, JGA

Duran, ME

Apam, MTR

Cañas, R

机构：

[1] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Fac Quim, Dept Organ, Mexico City 04510, DF, Mexico

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(02)00232-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report the regio- and stereoselective synthesis of a novel cis-C3N-C4X-C6N series (X=O, S, and C-2) from cyclic ketones. The cytotoxic activity of the now compounds was studied in five cell lines; the observed activities were in accordance with the concept of bioisosteric replacement. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：1675 / 1677

页数：3

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