The regulation of D2 dopamine receptor expression

被引：21

作者：

Hitzemann, RJ ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA

来源：

MOLECULAR PSYCHIATRY | 1998年 / 3卷 / 03期

关键词：

D O I：

10.1038/sj.mp.4000388

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The question of whether or not there is a polymorphism in or near DRD2 which is associated with receptor density remains unanswered. Both clinical and animal data demonstrate that D-2 dopamine receptor density is highly variable among individuals; differences of more than 100% are not uncommon. Among inbred mouse strains and F-2 intercrosses produced from these strains, it appears that most of the genetic variation in receptor expression is not associated with polymorphisms in or near Drd2.

引用

页码：198 / 203

页数：6

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