Charting histone modifications and the functional organization of mammalian genomes

被引：840

作者：

Zhou, Vicky W. ^{[1
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Goren, Alon ^{[1
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Bernstein, Bradley E. ^{[1
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机构：

[1] Massachusetts Gen Hosp, Howard Hughes Med Inst, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA

[5] Massachusetts Gen Hosp, Ctr Canc Res, Boston, MA 02114 USA

[6] MIT, Cambridge, MA 02142 USA

[7] Broad Inst Harvard, Cambridge, MA 02142 USA

[8] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

NATURE REVIEWS GENETICS | 2011年 / 12卷 / 01期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

EMBRYONIC STEM-CELLS; DNA METHYLATION; CHROMATIN-STRUCTURE; GENE-EXPRESSION; CPG ISLANDS; TRANSCRIPTIONAL COMPETENCE; HEMATOPOIETIC PROGENITORS; DEVELOPMENTAL REGULATORS; ACTIVE PROMOTERS; H3K4; METHYLATION;

D O I：

10.1038/nrg2905

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A succession of technological advances over the past decade have enabled researchers to chart maps of histone modifications and related chromatin structures with increasing accuracy, comprehensiveness and throughput. The resulting data sets highlight the interplay between chromatin and genome function, dynamic variations in chromatin structure across cellular conditions, and emerging roles for large-scale domains and higher-ordered chromatin organization. Here we review a selection of recent studies that have probed histone modifications and successive layers of chromatin structure in mammalian genomes, the patterns that have been identified and future directions for research.

引用

页码：7 / 18

页数：12

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