The complement system in liposome clearance: Can complement deposition be inhibited?

被引：56

作者：

Devine, DV

Bradley, AJ

机构：

[1] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V6T 2B5, Canada

[2] Canadian Red Cross Soc Blood Serv, Vancouver, BC, Canada

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1998年 / 32卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

complement; complement inhibition; liposome; liposome clearance;

D O I：

10.1016/S0169-409X(97)00129-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The activation of complement results in the opsonization of particles for removal by the reticuloendothelial system. Experimental evidence suggests that complement-mediated clearance of liposomal systems may significantly contribute to liposome biodistribution, Because of the multiplicity of complement activation mechanisms and the large number of proteins in the pathway, there are multiple opportunities to reduce or eliminate the opsonic effects of complement activation. This review addresses the state of our understanding of the interaction of liposomes with complement proteins and suggests some approaches to minimize complement activation. (C) 1998 Elsevier Science B.V.

引用

页码：19 / 29

页数：11

共 64 条

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