COX-2 inhibitors as radio sensitizing agents for cancer therapy

被引:21
作者
Davis, TW
Hunter, N
Trifan, OC
Milas, L
Masferrer, JL
机构
[1] Pharmacia Corp, Chesterfield, MO USA
[2] Pharmacia Corp, St Louis, MO USA
[3] Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA
来源
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 2003年 / 26卷 / 04期
关键词
celecoxib; prostaglandins; COX-2; radiation;
D O I
10.1097/01.COC.0000074158.59269.9F
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Prostaglandins have long been known to impact the radiosensitivity of cells and tissues, and many studies have centered on exploiting nonspecific prostaglandin inhibitors such as NSAIDs for therapeutic gain. These studies have ultimately been unsuccessful due to the lack of targeted specificity against the tumor. The discovery of the inducible cyclooxygenase enzyme (COX-2) and development of some highly selective inhibitors (which spare the constitutive COX-1 activity) has renewed excitement for modulating tumor prostaglandins as a method of specific radio-sensitization of tumors, while sparing normal tissues. This review discusses these new data and generates a rationale for use of COX-2 inhibitors as radiosensitizing agents in cancer therapy.
引用
收藏
页码:S58 / S61
页数:4
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