The ligand that came from within

被引：41

作者：

Piomelli, D ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2001年 / 22卷 / 01期

关键词：

D O I：

10.1016/S0165-6147(00)01602-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent evidence suggests that the endogenous activators of neuronal vanilloid (capsaicin) receptors should be sought inside, not outside, the neuron. 12-Lipoxygenase metabolites of arachidonic acid, produced by pain-inducing mediators such as bradykinin. might trigger vanilloid receptor activation by interacting with an intracellular site on the receptor. Are these lipid-like second messengers the long-sought endogenous vanilloids?

引用

页码：17 / 19

页数：3

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