Direct electrical measurements on single-molecule genomic DNA using single-walled carbon nanotubes

被引：99

作者：

Roy, Somenath ^{[1
]}

Vedala, Harindra ^{[1
]}

Roy, Aparna Datta ^{[1
]}

Kim, Do-Hyun ^{[1
]}

Doud, Melissa ^{[2
]}

Mathee, Kalai ^{[2
]}

Shin, Hoon-Kyu ^{[3
]}

Shimamoto, Nobuo ^{[4
]}

Prasad, Viswanath ^{[1
]}

Choi, Wonbong ^{[1
]}

机构：

[1] Florida Int Univ, Dept Mech & Mat Engn, Miami, FL 33174 USA

[2] Florida Int Univ, Dept Biol Sci, Miami, FL 33199 USA

[3] Pohang Univ Sci & Technol, Natl Ctr Nanomat Technol, Pohang 790784, South Korea

[4] Natl Inst Genet, Shizuoka 4118540, Japan

来源：

NANO LETTERS | 2008年 / 8卷 / 01期

关键词：

D O I：

10.1021/nl0716451

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A unique nanoelectronic platform, based on single-walled carbon nanotubes (SWNTs), has been fabricated for measuring electrical transport in single-molecule DNA. We have tested 80 base pairs of single- and double-stranded DNA (ssDNA and dsDNA, respectively) of complex base sequences. About a 25-40 pA current (at 1 V) was measured for the dsDNA molecule covalently attached to the SWNT electrode at its termini. In the absence of base pair stacking, a ssDNA carries a feeble current of similar to 1 pA or less. Gate-voltage-dependent V V characteristics revealed that the bridging dsDNA molecule acts as a p-type channel between SWNT source and drain electrodes.

引用

页码：26 / 30

页数：5

共 24 条

[1] DNA-templated assembly and electrode attachment of a conducting silver wire [J].

Braun, E ;

Eichen, Y ;

Sivan, U ;

Ben-Yoseph, G .

NATURE, 1998, 391 (6669) :775-778

[2] Carbon nanotube-enhanced electrochemical DNA biosensor for DNA hybridization detection [J].

Cai, H ;

Cao, XN ;

Jiang, Y ;

He, PG ;

Fang, YZ .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2003, 375 (02) :287-293

[3] Aligned carbon nanotubes for nanoelectronics [J].

Choi, WB ;

Bae, E ;

Kang, D ;

Chae, S ;

Cheong, BH ;

Ko, JH ;

Lee, EM ;

Park, W .

NANOTECHNOLOGY, 2004, 15 (10) :S512-S516

[4] Direct measurement of electrical transport through single DNA molecules of complex sequence [J].

Cohen, H ;

Nogues, C ;

Naaman, R ;

Porath, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (33) :11589-11593

[5]

DIVENTRA M, 2004, ENCY NANOSCIENCE NAN

[6] Electrical conduction through DNA molecules [J].

Fink, HW ;

Schönenberger, C .

NATURE, 1999, 398 (6726) :407-410

[7] Covalently bridging gaps in single-walled carbon nanotubes with conducting molecules [J].

Guo, XF ;

Small, JP ;

Klare, JE ;

Wang, YL ;

Purewal, MS ;

Tam, IW ;

Hong, BH ;

Caldwell, R ;

Huang, LM ;

O'Brien, S ;

Yan, JM ;

Breslow, R ;

Wind, SJ ;

Hone, J ;

Kim, P ;

Nuckolls, C .

SCIENCE, 2006, 311 (5759) :356-359

[8] Direct current electrical characterization of ds-DNA in nanogap junctions [J].

Iqbal, SM ;

Balasundaram, G ;

Ghosh, S ;

Bergstrom, DE ;

Bashir, R .

APPLIED PHYSICS LETTERS, 2005, 86 (15) :1-3

[9] Thickness and low-temperature conductivity of DNA molecules [J].

Kasumov, AY ;

Klinov, DV ;

Roche, PE ;

Guéron, S ;

Bouchiat, H .

APPLIED PHYSICS LETTERS, 2004, 84 (06) :1007-1009

[10] Transport phenomena and conduction mechanism of single-walled carbon nanotubes (SWNTs) at Y- and crossed-junctions [J].

Kim, Do-Hyun ;

Huang, Jun ;

Shin, Hoon-Kyu ;

Roy, Somenath ;

Choi, Wonbong .

NANO LETTERS, 2006, 6 (12) :2821-2825

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