Lentiviruses as gene transfer agents for delivery to non-dividing cells

被引：238

作者：

Naldini, L ^{[1
]}

机构：

[1] Cell Genesys, Foster City, CA 94404 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1998年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0958-1669(98)80029-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Lentiviral vectors are proving to be effective agents for the direct delivery and sustained expression of a transgene in several tissues, including brain, retina, muscle and liver. Significant progress was achieved in the biosafety of HIV-derived vectors by eliminating all the viral sequences nonessential for transduction. Other vectors have also been developed from non-primate lentiviruses.

引用

页码：457 / 463

页数：7