Mitochondrial DNA mutations, oxidative stress, and aging

被引：83

作者：

Golden, TR ^{[1
]}

Melov, S ^{[1
]}

机构：

[1] Buck Inst Age Res, Novato, CA 94945 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2001年 / 122卷 / 14期

关键词：

mitochondrial DNA; somatic mutations; oxidative stress; aging;

D O I：

10.1016/S0047-6374(01)00288-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Advances in understanding of mitochondrial physiology and genetics in relation to pathology have exploded in the last decade. Paralleling this increase has been an active debate about the role of mitochondrial oxidative stress with regard to mitochondrial DNA mutations, aging, and disease. We discuss in a historical context the rapid progress in our understanding of the role of mitochondrial DNA mutations in disease, mitochondrial oxidative stress in aging, and the potential interplay between these two phenomena. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：1577 / 1589

页数：13

共 88 条

[1]

AMES A, 1997, MITOCHONDRIA FREE RA, P309

[2] Endogenous oxidative damage of mtDNA [J].