The Natural Product Betulinic Acid Inhibits C/EBP Family Transcription Factors

被引：8

作者：

Hollis, Angela ^{[2
]}

Sperl, Bianca ^{[2
]}

Graeber, Martin ^{[1
]}

Berg, Thorsten ^{[1
,2
]}

机构：

[1] Univ Leipzig, Inst Organ Chem, D-04103 Leipzig, Germany

[2] CIPSM, Dept Mol Biol, Max Planck Inst Biochem, D-82152 Martinsried, Germany

来源：

CHEMBIOCHEM | 2012年 / 13卷 / 02期

关键词：

adipogenesis; inhibitors; natural products; protein-DNA interactions; transcription factors; BINDING-PROTEIN; DNA-BINDING; DIACYLGLYCEROL ACYLTRANSFERASE; MYC/MAX DIMERIZATION; SIGNAL TRANSDUCER; ASSAY; CHEMISTRY; APOPTOSIS; ACTIVATOR; OPINION;

D O I：

10.1002/cbic.201100652

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

引用

页码：302 / 307

页数：6

共 44 条

[1]

Betulinic acid derivatives as HIV-1 antivirals [J].

Aiken, C ;

Chen, CH .

TRENDS IN MOLECULAR MEDICINE, 2005, 11 (01) :31-36

[2]

Arndt H.D., 2006, ANGEW CHEM, V118, P4664

[3]

Small molecule modulators of transcription [J].

Arndt, Hans-Dieter .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (28) :4552-4560

[4]

Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts [J].

Berg, T ;

Cohen, SB ;

Desharnais, J ;

Sonderegger, C ;

Maslyar, DJ ;

Goldberg, J ;

Boger, DL ;

Vogt, PK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) :3830-3835

[5]

Inhibition of transcription factors with small organic molecules [J].

Berg, Thorsten .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2008, 12 (04) :464-471

[6]

Breinbauer R, 2002, ANGEW CHEM INT EDIT, V41, P2879

[7]

BREINBAUER R, 2002, ANGEW CHEM, V114, P3002

[8]

Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members [J].

Cases, S ;

Stone, SJ ;

Zhou, P ;

Yen, E ;

Tow, B ;

Lardizabal, KD ;

Voelker, T ;

Farese, RV .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (42) :38870-38876

[9]

Inhibition of diacylglycerol acyltransferase by betulinic acid from Alnus hirsuta [J].

Chung, MY ;

Rho, MC ;

Lee, SW ;

Park, HR ;

Kim, K ;

Lee, IA ;

Kim, DH ;

Jeune, KH ;

Lee, HS ;

Kim, YK .

PLANTA MEDICA, 2006, 72 (03) :267-269

[10]

Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection [J].

Cichewicz, RH ;

Kouzi, SA .

MEDICINAL RESEARCH REVIEWS, 2004, 24 (01) :90-114

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