Small molecule modulators of transcription

被引:53
作者
Arndt, Hans-Dieter
机构
[1] Univ Dortmund, Fachbereich Chem, D-44221 Dortmund, Germany
[2] Max Planck Inst Mol Physiol, D-44227 Dortmund, Germany
关键词
antitumor agents; coactivators; gene expression; protein-protein interactions; transcription factors;
D O I
10.1002/anie.200600285
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:4552 / 4560
页数:9
相关论文
共 72 条
[1]  
ANANDA A, 2001, PHYSIOL REV, V81, P1269
[2]   Modular design of artificial transcription factors [J].
Ansari, AZ ;
Mapp, AK .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (06) :765-772
[3]   Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream [J].
Arkin, MR ;
Wells, JA .
NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (04) :301-317
[4]   Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators [J].
Arnold, LA ;
Estébanez-Perpiñá, E ;
Togashi, M ;
Jouravel, N ;
Shelat, A ;
McReynolds, AC ;
Mar, E ;
Nguyen, P ;
Baxter, JD ;
Fletterick, RJ ;
Webb, P ;
Guy, RK .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (52) :43048-43055
[5]   Modulation of protein-protein interactions with small organic molecules [J].
Berg, T .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (22) :2462-2481
[6]   Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts [J].
Berg, T ;
Cohen, SB ;
Desharnais, J ;
Sonderegger, C ;
Maslyar, DJ ;
Goldberg, J ;
Boger, DL ;
Vogt, PK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) :3830-3835
[7]  
Berg T., 2003, ANGEW CHEM, V115, P2566
[8]   Identification of small-molecule antagonists that inhibit an activator: coactivator interaction [J].
Best, JL ;
Amezcua, CA ;
Mayr, B ;
Flechner, L ;
Murawsky, CM ;
Emerson, B ;
Zor, T ;
Gardner, KH ;
Montminy, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (51) :17622-17627
[9]   Linking colorectal cancer to Wnt signaling [J].
Bienz, M ;
Clevers, H .
CELL, 2000, 103 (02) :311-320
[10]  
Boger DL, 2000, HELV CHIM ACTA, V83, P1825, DOI 10.1002/1522-2675(20000809)83:8<1825::AID-HLCA1825>3.0.CO