Small molecule modulators of transcription

被引:53
作者
Arndt, Hans-Dieter
机构
[1] Univ Dortmund, Fachbereich Chem, D-44221 Dortmund, Germany
[2] Max Planck Inst Mol Physiol, D-44227 Dortmund, Germany
关键词
antitumor agents; coactivators; gene expression; protein-protein interactions; transcription factors;
D O I
10.1002/anie.200600285
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:4552 / 4560
页数:9
相关论文
共 72 条
[31]   Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis [J].
Koehler, AN ;
Shamji, AF ;
Schreiber, SL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (28) :8420-8421
[32]   Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC(-/-) colon carcinoma [J].
Korinek, V ;
Barker, N ;
Morin, PJ ;
vanWichen, D ;
deWeger, R ;
Kinzler, KW ;
Vogelstein, B ;
Clevers, H .
SCIENCE, 1997, 275 (5307) :1784-1787
[33]   Mediator and the mechanism of transcriptional activation [J].
Kornberg, RD .
TRENDS IN BIOCHEMICAL SCIENCES, 2005, 30 (05) :235-239
[34]   Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway [J].
Kung, AL ;
Zabludoff, SD ;
France, DS ;
Freedman, SJ ;
Tanner, EA ;
Vieira, A ;
Cornell-Kennon, S ;
Lee, J ;
Wang, BQ ;
Wang, JM ;
Memmert, K ;
Naegeli, HU ;
Petersen, F ;
Eck, MJ ;
Bair, KW ;
Wood, AW ;
Livingston, DM .
CANCER CELL, 2004, 6 (01) :33-43
[35]   Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain [J].
Kussie, PH ;
Gorina, S ;
Marechal, V ;
Elenbaas, B ;
Moreau, J ;
Levine, AJ ;
Pavletich, NP .
SCIENCE, 1996, 274 (5289) :948-953
[36]   Small molecule transcription factor mimic [J].
Kwonj, Y ;
Arndt, HD ;
Qian, M ;
Choi, Y ;
Kawazoe, Y ;
Dervan, PB ;
Uesugi, M .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (49) :15940-15941
[37]   Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions [J].
Leduc, AM ;
Trent, JO ;
Wittliff, JL ;
Bramlett, KS ;
Briggs, SL ;
Chirgadze, NY ;
Wang, Y ;
Burris, TP ;
Spatola, AF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (20) :11273-11278
[38]   Transcription of eukaryotic protein-coding genes [J].
Lee, TI ;
Young, RA .
ANNUAL REVIEW OF GENETICS, 2000, 34 :77-137
[39]   Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex [J].
Lepourcelet, M ;
Chen, YNP ;
France, DS ;
Wang, HS ;
Crews, P ;
Petersen, F ;
Bruseo, C ;
Wood, AW ;
Shivdasani, RA .
CANCER CELL, 2004, 5 (01) :91-102
[40]   Transcription regulation and animal diversity [J].
Levine, M ;
Tjian, R .
NATURE, 2003, 424 (6945) :147-151