Nepetalactone:: A new opioid analgesic from Nepeta caesarea Boiss.

被引:50
作者
Aydin, S
Beis, R
Öztürk, Y
Hüsnü, K
Baser, KHC
机构
[1] Anadolu Univ, Fac Pharm, Dept Pharmacol, TR-26470 Eskisehir, Turkey
[2] Anadolu Univ, Fac Pharm, Dept Pharmacognosy, TR-26470 Eskisehir, Turkey
[3] Anadolu Univ, Aromat Plant & Drug Res Ctr, TR-26470 Eskisehir, Turkey
关键词
D O I
10.1111/j.2042-7158.1998.tb07145.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The essential oils of Nepeta species including Nepeta phyllochlamys P. H. Davis, N. nuda L. ssp. nude, and N. caesarea Boiss. have been screened by use of the tail-flick and tail immersion (52.5 degrees C) methods. Of the species studied, only N. caesarea showed significant analgesic activity, besides marked sedation, which was also blocked by naloxone, indicating involvement of opioid receptors. Moreover, it was only active on mechanical, not thermal, algesic response which suggests specificity for specific opioid receptor subtypes, excluding mu-opioid receptors. Because 4a alpha,7 alpha,7a alpha-nepetalactone is the main component of the essential oil of N. caesarea, and is present at very high levels (92-95%), it is concluded that 4a alpha,7 alpha,7a alpha-nepetalactone is the active principle and has a specific opioid receptor subtype agonistic activity.
引用
收藏
页码:813 / 817
页数:5
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