Antinociceptive effect of some amaryllidaceae plants in mice

被引:10
作者
Cakici, I [1 ]
Ulug, HY [1 ]
Inci, S [1 ]
Tunctan, B [1 ]
Abacioglu, N [1 ]
Kanzik, I [1 ]
Sener, B [1 ]
机构
[1] GAZI UNIV,FAC PHARM,DEPT PHARMACOGNOSY,TR-06330 HIPODROM,ANKARA,TURKEY
关键词
D O I
10.1111/j.2042-7158.1997.tb06121.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The antinociceptive effects of ethanolic extracts of Pancratium maritimum L., Narcissus tazetta subspecies tazetta and Leucojum aestivum L. bulbs have been investigated in mice using the p-benzoquinone-induced abdominal constriction and hot-plate tests. In the p-benzoquinone-induced abdominal constriction test the ethanolic extracts of P. maritimum (300, 600 or 1200 mg kg(-1), s.c.) and N. tazetta subsp. tazetta (5, 50, 100 or 200 mg kg(-1), s.c.) caused dose-dependent inhibition of abdominal constrictions whereas a fluctuating response was obtained from ethanolic extracts of L. aestivum (2.5-500 mg kg(-1), s.c.), In the hot-plate test P. maritimum and L. aestivum caused a significant increase of latency only at the highest concentrations used (1200 mg kg(-1) and 500 mg kg(-1), i.p., respectively). However, at these concentrations they also caused significant toxic effects. In contrast with P. maritimum and L. aestivum, N. tazetta subsp. tazetta (5-500 mg kg(-1), i.p.) extracts had no antinociceptive effect in this test. These Findings indicate that the antinociceptive effect of Amaryllidaceae plants differs depending on the model of nociception investigated.
引用
收藏
页码:828 / 830
页数:3
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