ANTINEOPLASTIC AGENTS .301. AN INVESTIGATION OF THE AMARYLLIDACEAE GENUS HYMENOCALLIS

被引：56

作者：

PETTIT, GR

GROSZEK, G

BACKHAUS, RA

DOUBEK, DL

BARR, RJ

MEEROW, AW

机构：

[1] ARIZONA STATE UNIV,DEPT BOT,TEMPE,AZ 85287

[2] UNIV FLORIDA,REC,FT LAUDERDALE,FL 33314

来源：

JOURNAL OF NATURAL PRODUCTS-LLOYDIA | 1995年 / 58卷 / 05期

关键词：

D O I：

10.1021/np50119a017

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Seven species (and one cultivated variety) of Hymenocallis (Amaryllidaceae) and the related Pancratium maritima, representing a broad geographical selection, were investigated as sources of pancracistatin [1] now undergoing preclinical development as an anticancer agent. Pancratistatin [1] was found to be a constituent of H, speciosa (Singapore), H, variegated (Singapore), H. pedalis (Seychelles), H, expansa (Bermuda), H. sonoranensis (Mexico), and P. maritimum (Israel). Only two species of Hymenocallis failed to yield one or more of the related cell-growth inhibitory isocarbostyrils such as narciclasine [3a], 7-deoxynarciclasine [3b], and 7-deoxy-trans-dihydronarciclasine [2].

引用

页码：756 / 759

页数：4

共 12 条

[1] NARCICLASINE-4-O-BETA-D-GLUCOPYRANOSIDE, A GLUCOSYLOXY AMIDIC PHENANTHRIDONE DERIVATIVE FROM PANCRATIUM-MARITIMUM [J].

ABOUDONIA, AH ;

DEGIULIO, A ;

EVIDENTE, A ;

GABER, M ;

HABIB, AA ;

LANZETTA, R ;

ELDIN, AAS .

PHYTOCHEMISTRY, 1991, 30 (10) :3445-3448

[2]

Backhaus R. A., 1992, Acta Horticulturae, P364

[3] ANTIVIRAL (RNA) ACTIVITY OF SELECTED AMARYLLIDACEAE ISOQUINOLINE CONSTITUENTS AND SYNTHESIS OF RELATED SUBSTANCES [J].

GABRIELSEN, B ;

MONATH, TP ;

HUGGINS, JW ;

KEFAUVER, DF ;

PETTIT, GR ;

GROSZEK, G ;

HOLLINGSHEAD, M ;

KIRSI, JJ ;

SHANNON, WM ;

SCHUBERT, EM ;

DARE, J ;

UGARKAR, B ;

USSERY, MA ;

PHELAN, MJ .

JOURNAL OF NATURAL PRODUCTS, 1992, 55 (11) :1569-1581

[4]

GABRIELSEN B, 1992, NATURAL PRODUCTS AS ANTIVIRAL AGENTS, P121

[5] ANTINEOPLASTIC AGENTS .162. ZEPHYRANTHES-CANDIDA [J].

PETTIT, GR ;

CRAGG, GM ;

SINGH, SB ;

DUKE, JA ;

DOUBEK, DL .

JOURNAL OF NATURAL PRODUCTS, 1990, 53 (01) :176-178

[6] ANTINEOPLASTIC AGENTS .95. ISOLATION AND STRUCTURE OF PANCREATISTATIN [J].

PETTIT, GR ;

GADDAMIDI, V ;

CRAGG, GM ;

HERALD, DL ;

SAGAWA, Y .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1984, (24) :1693-1694

[7] ANTINEOPLASTIC AGENTS .105. ZEPHYRANTHES-GRANDIFLORA [J].

PETTIT, GR ;

GADDAMIDI, V ;

CRAGG, GM .

JOURNAL OF NATURAL PRODUCTS, 1984, 47 (06) :1018-1020

[8] ANTINEOPLASTIC AGENTS .120. PANCRATIUM-LITTORALE [J].

PETTIT, GR ;

GADDAMIDI, V ;

HERALD, DL ;

SINGH, SB ;

CRAGG, GM ;

SCHMIDT, JM ;

BOETTNER, FE ;

WILLIAMS, M ;

SAGAWA, Y .

JOURNAL OF NATURAL PRODUCTS, 1986, 49 (06) :995-1002

[9] ANTINEOPLASTIC AGENTS-300 - ISOLATION AND STRUCTURE OF THE RARE HUMAN CANCER INHIBITORY MACROCYCLIC LACTONES SPONGISTATIN-8 AND SPONGISTATIN-9 [J].

PETTIT, GR ;

CICHACZ, ZA ;

HERALD, CL ;

GAO, F ;

BOYD, MR ;

SCHMIDT, JM ;

HAMEL, E ;

BAI, RL .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1994, (13) :1605-1606

[10] ANTINEOPLASTIC AGENTS .256. CELL-GROWTH INHIBITORY ISOCARBOSTYRILS FROM HYMENOCALLIS [J].

PETTIT, GR ;

BACKHAUS, RA ;

BOYD, MR ;

MEEROW, AW .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (10) :1682-1687

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