ANTINEOPLASTIC AGENTS-300 - ISOLATION AND STRUCTURE OF THE RARE HUMAN CANCER INHIBITORY MACROCYCLIC LACTONES SPONGISTATIN-8 AND SPONGISTATIN-9

被引：84

作者：

PETTIT, GR

CICHACZ, ZA

HERALD, CL

GAO, F

BOYD, MR

SCHMIDT, JM

HAMEL, E

BAI, RL

机构：

[1] ARIZONA STATE UNIV,DEPT CHEM,TEMPE,AZ 85287

[2] NCI,FREDERICK CANC RES & DEV CTR,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,FREDERICK,MD 21702

[3] NCI,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,MOLEC PHARMACOL LAB,BETHESDA,MD 20892

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 13期

关键词：

D O I：

10.1039/c39940001605

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two trace (0.7 and 2.2 x 10(-7)% yields) potent antineoplastic macrocyclic lactones termed spongistatins 8 (2a) and 9 (2b) have been isolated from the African marine sponge Spirastrella spinispirulifera and found to be very potent inhibitors of glutamate-induced tubulin polymerization.

引用

页码：1605 / 1606

页数：2

共 22 条

[1] DOLASTATIN-10, A POWERFUL CYTOSTATIC PEPTIDE DERIVED FROM A MARINE ANIMAL - INHIBITION OF TUBULIN POLYMERIZATION MEDIATED THROUGH THE VINCA ALKALOID BINDING DOMAIN [J].