Current issues in mouse genome engineering

被引：123

作者：

Glaser, S ^{[1
]}

Anastassiadis, K ^{[1
]}

Stewart, AF ^{[1
]}

机构：

[1] Tech Univ Dresden, Bioinnovat Zentrum, D-01307 Dresden, Germany

来源：

NATURE GENETICS | 2005年 / 37卷 / 11期

关键词：

D O I：

10.1038/ng1668

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mouse is the foremost vertebrate experimental model because its genome can be precisely and variously engineered. Now that the mouse genome has been sequenced and annotated, the task of mutating each gene is feasible, and an international cooperation is providing mutated embryonic stem cells and mice as readily available resources. Because these resources will change biomedical research, decisions about their nature will have far-reaching effects. It is therefore timely to consider topical issues for mouse genome engineering, such as the background genotype; homologous, site-specific and transpositional recombination; conditional mutagenesis; RNA-mediated interference; and functional genomics with embryonic stem cells.

引用

页码：1187 / 1193

页数：7

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