Engineering Cell Surface Function with DNA Origami

被引：99

作者：

Akbari, Ehsan ^{[1
]}

Mollica, Molly Y. ^{[1
]}

Lucas, Christopher R. ^{[1
]}

Bushman, Sarah M. ^{[2
]}

Patton, Randy A. ^{[1
]}

Shahhosseini, Melika ^{[1
]}

Song, Jonathan W. ^{[3
]}

Castro, Carlos E. ^{[4
]}

机构：

[1] Ohio State Univ, Dept Mech & Aerosp Engn, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Biomed Engn, Columbus, OH 43210 USA

[3] Ohio State Univ, Ctr Comprehens Canc, Dept Mech & Aerosp Engn, Columbus, OH 43210 USA

[4] Ohio State Univ, Biophys Grad Program, Dept Mech & Aerosp Engn, Columbus, OH 43210 USA

来源：

ADVANCED MATERIALS | 2017年 / 29卷 / 46期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

cell surface engineering; DNA nanotechnology; DNA origami; intercellular adhesion; membrane functionalization; MEMBRANE; NANOSTRUCTURES; GROWTH; MECHANISMS; TRANSPORT; LEUKEMIA; CULTURE; SHAPES;

D O I：

10.1002/adma.201703632

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A specific and reversible method is reported to engineer cell-membrane function by embedding DNA-origami nanodevices onto the cell surface. Robust membrane functionalization across epithelial, mesenchymal, and nonadherent immune cells is achieved with DNA nanoplatforms that enable functions including the construction of higher-order DNA assemblies at the cell surface and programed cell-cell adhesion between homotypic and heterotypic cells via sequence-specific DNA hybridization. It is anticipated that integration of DNA-origami nanodevices can transform the cell membrane into an engineered material that can mimic, manipulate, and measure biophysical and biochemical function within the plasma membrane of living cells.

引用

页数：9

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