Phosphodiesterase type 5 (PDE5) in the adipocyte: a novel player in fat metabolism?

被引：50

作者：

Armani, Andrea ^{[1
]}

Marzolla, Vincenzo ^{[2
]}

Rosano, Giuseppe M. C. ^{[1
]}

Fabbri, Andrea ^{[3
]}

Caprio, Massimiliano ^{[1
]}

机构：

[1] Sci Inst Res Hospitalizat & Hlth Care IRCCS San R, Ctr Clin & Basic Res, Rome, Italy

[2] San Raffaele Sulmona, Sulmona, AQ, Italy

[3] Univ Roma Tor Vergata, Endocrinol Unit, St Eugenio & CTO A Alesini Hosp, Rome, Italy

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2011年 / 22卷 / 10期

关键词：

NITRIC-OXIDE; ADIPOSE-TISSUE; AROMATASE EXPRESSION; PROTEIN-KINASE; CREB PHOSPHORYLATION; NATRIURETIC PEPTIDES; ADIPOGENESIS; CGMP; ACTIVATION; ESTROGEN;

D O I：

10.1016/j.tem.2011.05.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Phosphodiesterase type 5 (PDE5) is expressed in many tissues (e.g. heart, lung, pancreas, penis) and plays a specific role in hydrolyzing cyclic guanosine monophosphate (cGMP). In adipocytes, cGMP regulates crucial functions by activating cGMP-dependent protein kinase (PKG). Interestingly, PDE5 was recently identified in adipose tissue, although its role remains unclear. Its inhibition, however, was recently shown to affect adipose differentiation and aromatase function. This review summarizes evidence supporting a role for the PDE5-regulated cGMP/PKG system in adipose tissue and its effects on adipocyte function. A better elucidation of the role of PDE5 in the adipocyte could reveal new therapeutic strategies for fighting obesity and metabolic syndrome.

引用

页码：404 / 411

页数：8

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