Alginate/starch blend fibers and their properties for drug controlled release

被引：176

作者：

Wang, Qun ^{[1
]}

Hu, Xianwen ^{[2
]}

Du, Yumin ^{[1
]}

Kennedy, John F. ^{[3
]}

机构：

[1] Wuhan Univ, Dept Environm Sci, Wuhan 430072, Peoples R China

[2] Huazhong Agr Univ, Dept Chem, Coll Sci, Wuhan 430070, Peoples R China

[3] Inst Adv Sci & Technol, Chembiotech Labs, Bromsgrove B60 4JE, Worcs, England

来源：

CARBOHYDRATE POLYMERS | 2010年 / 82卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Alginate; Blend; Fibers; Drug release system; IN-VITRO RELEASE; CROSS-LINKING; PERVAPORATION; TABLETS; CALCIUM; MATRIX;

D O I：

10.1016/j.carbpol.2010.06.004

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Fibers of alginate and starch, with salicylic acid (SA) as model drug incorporated in different concentrations, were obtained by spinning their solution through a viscose-type spinneret into a coagulating bath containing aqueous CaCl2 and ethanol. Chemical, morphological and mechanical properties characterization was carried out, as well as the studies of the factors that influence the drug releasing from alginate/starch fibers. The results of controlled release tests showed that the amount of SA released increased with an increase in the proportion of starch present in the fiber. Moreover, the release rate of drug decreased as the amount of drug loaded in the fiber increased, but the cumulative release amount is increasing. The alginate/starch fibers were also sensitive to pH and ionic strength. All the results indicated that the alginate/starch fiber was potentially useful in drug delivery systems. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：842 / 847

页数：6

共 22 条

[1]

Evaluation of parameters involved in preparation and release of drug loaded in crosslinked matrices of alginate [J].