IL-22 Induces an Acute-Phase Response

被引：138

作者：

Liang, Spencer C. ^{[1
]}

Nickerson-Nutter, Cheryl ^{[1
]}

Pittman, Debra D. ^{[2
]}

Carrier, Yijun ^{[1
]}

Goodwin, Debra G. ^{[1
]}

Shields, Kathleen M. ^{[2
]}

Lambert, Andre-Jean ^{[3
]}

Schelling, Scott H. ^{[3
]}

Medley, Quintus G. ^{[1
]}

Ma, Hak-Ling ^{[1
]}

Collins, Mary ^{[1
]}

Dunussi-Joannopoulos, Kyriaki ^{[1
]}

Fouser, Lynette A. ^{[1
]}

机构：

[1] Pfizer Biotherapeut Res & Dev, Inflammat & Immunol Res Unit, Cambridge, MA 02140 USA

[2] Pfizer Biotherapeut Res & Dev, Biocorrect Res Unit, Cambridge, MA 02140 USA

[3] Pfizer Global Drug Safety Res & Dev, Andover, MA 01810 USA

来源：

JOURNAL OF IMMUNOLOGY | 2010年 / 185卷 / 09期

关键词：

SERUM-AMYLOID-A; T-CELL; MOUSE MODEL; INTERLEUKIN (IL)-22; RECEPTOR COMPLEXES; MEDIATED TRANSFER; INDUCIBLE FACTOR; CUTTING EDGE; HOST-DEFENSE; TH17; CELLS;

D O I：

10.4049/jimmunol.0904091

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-22 is made by a unique set of innate and adaptive immune cells, including the recently identified noncytolytic NK, lymphoid tissue-inducer, Th17, and Th22 cells. The direct effects of IL-22 are restricted to nonhematopoietic cells, its receptor expressed on the surface of only epithelial cells and some fibroblasts in various organs, including parenchymal tissue of the gut, lung, skin, and liver. Despite this cellular restriction on IL-22 activity, we demonstrate that IL-22 induces effects on systemic biochemical, cellular, and physiological parameters. By utilizing adenoviral-mediated delivery of IL-22 and systemic administration of IL-22 protein, we observed that IL-22 modulates factors involved in coagulation, including fibrinogen levels and platelet numbers, and cellular constituents of blood, such as neutrophil and RBC counts. Furthermore, we observed that IL-22 induces thymic atrophy, body weight loss, and renal proximal tubule metabolic activity. These cellular and physiological parameters are indicative of a systemic inflammatory state. We observed that IL-22 induces biochemical changes in the liver including induction of fibrinogen, CXCL1, and serum amyloid A that likely contribute to the reported cellular and physiological effects of IL-22. Based on these findings, we propose that downstream of its expression and impact in local tissue inflammation, circulating IL-22 can further induce changes in systemic physiology that is indicative of an acute-phase response. The Journal of Immunology, 2010, 185: 5531-5538.

引用

页码：5531 / 5538

页数：8

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