Transcripts of the gene encoding the serotonin 2C receptor are modified by RNA editing, a posttranscriptional process that converts adenosines to inosines. This editing changes up to three genomically encoded amino acids located in the second intracellular loop of the G-protein-coupled receptor. Compared with nonedited receptors, extensively edited receptor isoforms activate G protein less efficiently. Studies on mice revealed that 5-HT2C pre-mRNA editing is regulated in a serotonin-dependent manner, and postmortem studies on brain tissues of patients with schizophrenia and major depression found distinct site-specific alterations of this editing in the prefrontal cortex, a brain region expressing a large number of differently edited 5-HT2C mRNA isoforms. At present, the most complex alterations in 5-HT2C pre-mRNA editing were found in brains of depressed suicide victims. In these brains, 5-HT2C receptor isoforms with reduced function are expressed at significantly increased levels, suggesting that the regulation of editing by synaptic serotonin is defective.
机构:
Western Gen Hosp, Human Genet Unit, MRC, Edinburgh EH4 2XU, Midlothian, ScotlandWestern Gen Hosp, Human Genet Unit, MRC, Edinburgh EH4 2XU, Midlothian, Scotland
Keegan, LP
;
Gallo, A
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Western Gen Hosp, Human Genet Unit, MRC, Edinburgh EH4 2XU, Midlothian, ScotlandWestern Gen Hosp, Human Genet Unit, MRC, Edinburgh EH4 2XU, Midlothian, Scotland
Gallo, A
;
O'Connell, MA
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Western Gen Hosp, Human Genet Unit, MRC, Edinburgh EH4 2XU, Midlothian, ScotlandWestern Gen Hosp, Human Genet Unit, MRC, Edinburgh EH4 2XU, Midlothian, Scotland
机构:
Western Gen Hosp, Human Genet Unit, MRC, Edinburgh EH4 2XU, Midlothian, ScotlandWestern Gen Hosp, Human Genet Unit, MRC, Edinburgh EH4 2XU, Midlothian, Scotland
Keegan, LP
;
Gallo, A
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h-index: 0
机构:
Western Gen Hosp, Human Genet Unit, MRC, Edinburgh EH4 2XU, Midlothian, ScotlandWestern Gen Hosp, Human Genet Unit, MRC, Edinburgh EH4 2XU, Midlothian, Scotland
Gallo, A
;
O'Connell, MA
论文数: 0引用数: 0
h-index: 0
机构:
Western Gen Hosp, Human Genet Unit, MRC, Edinburgh EH4 2XU, Midlothian, ScotlandWestern Gen Hosp, Human Genet Unit, MRC, Edinburgh EH4 2XU, Midlothian, Scotland