DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

被引：421

作者：

Durocher, D

Jackson, SP

机构：

[1] Univ Cambridge, Wellcome Trust & Canc Res Campaign, Inst Canc & Dev Biol, Cambridge CB2 1QR, England

[2] Univ Cambridge, Dept Zool, Cambridge CB2 1QR, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(00)00201-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The DNA damage signalling pathway is a core element of the cellular response to genotoxic insult, and its components play key roles in defending against neoplastic transformation. Recent work has indicated that the human ATM and ATR proteins, and their yeast homologues, are intimately involved in sensing DNA damage, suggesting parallels with the DNA double-strand break repair enzyme DNA-PK.

引用

页码：225 / 231

页数：7

共 66 条

[21] GARVIK B, 1995, MOL CELL BIOL, V15, P6128
[22] Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity
Gately, DP
Hittle, JC
Chan, GKT
Yen, TJ
[J]. MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (09) : 2361 - 2374
[23] THE DNA-DEPENDENT PROTEIN-KINASE - REQUIREMENT FOR DNA ENDS AND ASSOCIATION WITH KU ANTIGEN
GOTTLIEB, TM
JACKSON, SP
[J]. CELL, 1993, 72 (01) : 131 - 142
[24] Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
Guo, ZJ
Kumagai, A
Wang, SX
Dunphy, WG
[J]. GENES & DEVELOPMENT, 2000, 14 (21) : 2745 - 2756
[25] ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK
Hall-Jackson, CA
Cross, DAE
Morrice, N
Smythe, C
[J]. ONCOGENE, 1999, 18 (48) : 6707 - 6713
[26] DNA-dependent protein kinase: DNA binding and activation in the absence of Ku
Hammarsten, O
Chu, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (02) : 525 - 530
[27] DNA-DEPENDENT PROTEIN-KINASE CATALYTIC SUBUNIT - A RELATIVE OF PHOSPHATIDYLINOSITOL 3-KINASE AND THE ATAXIA-TELANGIECTASIA GENE-PRODUCT
HARTLEY, KO
GELL, D
SMITH, GCM
ZHANG, H
DIVECHA, N
CONNELLY, MA
ADMON, A
LEESMILLER, SP
ANDERSON, CW
JACKSON, SP
[J]. CELL, 1995, 82 (05) : 849 - 856
[28] The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase
Jhappan, C
Yusufzai, TM
Anderson, S
Anver, MR
Merlino, G
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (11) : 4075 - 4083
[29] A MAMMALIAN-CELL CYCLE CHECKPOINT PATHWAY UTILIZING P53 AND GADD45 IS DEFECTIVE IN ATAXIA-TELANGIECTASIA
KASTAN, MB
ZHAN, QM
ELDEIRY, WS
CARRIER, F
JACKS, T
WALSH, WV
PLUNKETT, BS
VOGELSTEIN, B
FORNACE, AJ
[J]. CELL, 1992, 71 (04) : 587 - 597
[30] Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage
Khosravi, R
Maya, R
Gottlieb, T
Oren, M
Shiloh, Y
Shkedy, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) : 14973 - 14977

← 1 2 3 4 5 6 7 →