Antitussive stemoninine alkaloids from the roots of Stemona tuberosa

被引：46

作者：

Lin, Li-Gen ^{[1
]}

Li, Kan Man ^{[2
]}

Tang, Chun-Ping ^{[1
]}

Ke, Chang-Qiang ^{[1
]}

Rudd, John A. ^{[2
]}

Lin, Ge ^{[2
]}

Ye, Yang ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[2] Chinese Univ Hong Kong, Dept Pharmacol, Hong Kong, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 06期

关键词：

D O I：

10.1021/np070651+

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Investigation of the roots of Stemona tuberosa afforded five minor constituents, stemoenonine (1), 9a-0-methylstemoenonine (2), oxystemoenonine (3), 1,9a-seco-stemoenonine (4), and oxystemoninine (5), along with the known compound stemoninoamide (6). Their structures were elucidated by 1D and 2D NMR spectra and other spectroscopic studies. Alkaloids 1, 2, and 6, as well as the representative stemoninine-type alkaloid, stemoninine (7), were screened for antitussive activity in the citric acid-induced guinea pig cough model. Compounds 6 and 7 exhibited strong antitussive activity after oral and intraperitoneal administrations.

引用

页码：1107 / 1110

页数：4

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