Stemoninines from the roots of Stemona tuberosa

被引：72

作者：

Lin, Li-Gen

Zhong, Qiong-Xing

Cheng, Tin-Yan

Tang, Chun-Ping

Ke, Chang-Qiang

Lin, Ge

Ye, Yang

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[2] Hainan Normal Univ, Dept Biol, Haikou 571158, Peoples R China

[3] Chinese Univ Hong Kong, Dept Pharmacol, Hong Kong, Hong Kong, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 07期

关键词：

D O I：

10.1021/np0505317

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new stemoninine-type alkaloids, bisdehydrostemoninine ( 1), isobisdehydrostemoninine ( 2), bisdehydroneostemoninine ( 3), and bisdehydrostemoninines A ( 4) and B ( 5), were isolated from the crude-alkaloid extract of the roots of Stemona tuberosa. Their structures were elucidated on the basis of one- and two-dimensional NMR and other spectroscopic studies. The relative configuration of 4 was determined by X-ray diffraction. Alkaloid 1 displayed significant antitussive activity in the citric acid-induced guinea pig cough model.

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页码：1051 / 1054

页数：4

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