Antibiotic biosynthesis: from natural to unnatural compounds

被引：25

作者：

Floss, HG ^{[1
]}

机构：

[1] Univ Washington, Dept Chem, Seattle, WA 98195 USA

来源：

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY | 2001年 / 27卷 / 03期

关键词：

antibiotic biosynthesis; rifamycins; granaticin; deoxysugar formation; polyketide synthases; actinomycete genetics;

D O I：

10.1038/sj.jim.7000069

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The evolution of the field of biosynthesis from the unravelling of the mode of formation of natural products to the use of such knowledge to create new compounds is reviewed using examples from the author's laboratory. The discussion focuses on the mode of operation of type II (spore pigment PKS) and type I (rifamycin PKS) polyketide synthases and their diversion to generate unnatural products, and on the genetics and biochemistry of deoxysugar formation in granaticin biosynthesis as a prerequisite to combinatorial enzymatic synthesis of unusual glycosides.

引用

收藏

页码：183 / 194

页数：12

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