Targeted lymph node immunization can protect cats from a mucosal challenge with feline immunodeficiency virus

被引：27

作者：

Finerty, S ^{[1
]}

Stokes, CR ^{[1
]}

Gruffydd-Jones, TJ ^{[1
]}

Hillman, TJ ^{[1
]}

Barr, FJ ^{[1
]}

Harbour, DA ^{[1
]}

机构：

[1] Univ Bristol, Dept Vet Clin Sci, Bristol BS40 5DU, Avon, England

来源：

VACCINE | 2001年 / 20卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

feline immunodeficiency virus; targeted lymph node immunization; mucosal infection;

D O I：

10.1016/S0264-410X(01)00323-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

With the rapid spread of human immunodeficiency virus (HIV) infection worldwide it is clear that effective strategies for mucosal vaccination against lentiviruses are urgently required. The aim of the present study is to determine whether protective immune responses against a mucosal challenge by feline immunodeficiency vir-us (FIV) can be elicited by targeting the immunization to the medial iliac lymph nodes - the principal site of migration of cells from the genital and rectal mucosa. Cats were challenged with homologous FIV via the rectal route. Targeted lymph node immunization was found to be an effective route of immunization eliciting both humoral and proliferative responses to peptide-based and fixed cell vaccines. Vaccination with fixed virus infected cells elicited protection against a cell-free mucosal FIV challenge. In addition, some cats vaccinated with fixed uninfected cells also remained uninfected following a cell-associated FIV challenge. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：49 / 58

页数：10

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