Iron-catalyzed alkenylation of Grignard reagents by enol phosphates

被引：59

作者：

Cahiez, Gerard ^{[1
]}

Gager, Olivier ^{[1
]}

Habiak, Vanessa ^{[1
]}

机构：

[1] CNRS UCP ESCOM, UMR 8123, Lab Synth Organ Select & Chim Organomet, F-95031 Neuville Sur Oise, Cergy Pontoise, France

来源：

SYNTHESIS-STUTTGART | 2008年 / 16期

关键词：

cross-coupling; Grignard reactions; iron; alkenes; stereoselectivity;

D O I：

10.1055/s-2008-1067194

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereoselective preparation of trisubstituted olefins can be easily performed from an Z/E-mixture of enol phosphates by reacting only the E-isomer with a Grignard reagent in the presence of Fe(acac)(3). This procedure combines a kinetic differentiation and a stereoselective reaction. The coupling is very chemoselective in the presence of an alkyl chloride, an ester, a ketone or a nitrile.

引用

页码：2636 / 2644

页数：9

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