Revitalizing membrane rafts: new tools and insights

被引:956
作者
Simons, Kai [1 ]
Gerl, Mathias J. [1 ]
机构
[1] Max Planck Inst Cell Biol & Genet, D-01307 Dresden, Germany
关键词
T-CELL-RECEPTOR; GPI-ANCHORED PROTEINS; HUMAN-IMMUNODEFICIENCY-VIRUS; PLASMA-MEMBRANE; LIPID RAFTS; PHASE-SEPARATION; FLUORESCENCE CORRELATION; NANOSCALE ORGANIZATION; CRITICAL FLUCTUATIONS; DOMAIN FORMATION;
D O I
10.1038/nrm2977
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Ten years ago, we wrote a Review on lipid rafts and signalling in the launch issue of Nature Reviews Molecular Cell Biology. At the time, this field was suffering from ambiguous methodology and imprecise nomenclature. Now, new techniques are deepening our insight into the dynamics of membrane organization. Here, we discuss how the field has matured and present an evolving model in which membranes are occupied by fluctuating nanoscale assemblies of sphingolipids, cholesterol and proteins that can be stabilized into platforms that are important in signalling, viral infection and membrane trafficking.
引用
收藏
页码:688 / 699
页数:12
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