Co-delivery of hydrophobic and hydrophilic drugs from nanoparticle-aptamer bioconjugates

被引：219

作者：

Zhang, Liangfang

Radovic-Moreno, Aleksandar F.

Alexis, Frank

Gu, Frank X.

Basto, Pamela A.

Bagalkot, Vaishali

Jon, Sangyong

Langer, Robert S.

Farokhzad, Omid C.

机构：

[1] Department of Anaesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115

[2] Department of Chemical Engineering, Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139

[3] Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500712, 1 Oryoung-dong, Buk-gu

来源：

CHEMMEDCHEM | 2007年 / 2卷 / 09期

关键词：

PROSTATE-CANCER CELLS; IN-VIVO; BINDING; SYSTEMS;

D O I：

10.1002/cmdc.200700121

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(Figure Presented) Herein we report a novel targeted drug delivery system consisting of nanoparticle-aptamer bioconjugates,which can carry both hydrophobic and hydrophilic chemotherapeutic drugs simultaneously, and deliver them selectively in a targeted and temporally distinct manner. This work provides a robust platform for targeted co-delivery of chemotherapeutic agents with the hope of both leveraging the synergistic effects of multiple drugs and also potentially suppressing the likelihood of drug resistance by the treated tissues. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1268 / 1271

页数：4

共 18 条

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