The epigenetic landscape of addiction

被引：149

作者：

Maze, Ian ^{[1
]}

Nestler, Eric J. ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Fishberg Dept Neurosci, New York, NY 10029 USA

来源：

ADDICTION REVIEWS | 2011年 / 1216卷

关键词：

histone; chromatin; plasticity; histone deacetylase (HDAC); histone methyltransferase (HMT); drug addiction; COCAINE-INDUCED PLASTICITY; MEDIUM SPINY NEURONS; GENOME-WIDE ANALYSIS; HISTONE DEACETYLASE; NUCLEUS-ACCUMBENS; GENE-EXPRESSION; TRANSCRIPTIONAL MECHANISMS; BEHAVIORAL SENSITIZATION; CHROMATIN MODIFICATIONS; SYNAPTIC PLASTICITY;

D O I：

10.1111/j.1749-6632.2010.05893.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Drug-induced alterations in gene expression throughout the reward circuitry of the brain are likely components of the persistence of the drug-addicted state. Recent studies examining the molecular mechanisms controlling drug-induced transcriptional, behavioral, and synaptic plasticity have indicated a direct role for chromatin remodeling in the regulation and stability of drug-mediated neuronal gene programs, and the subsequent promulgation of addictive behaviors. In this review, we discuss recent advances in our understanding of chromatin phenomena-or epigenetics, by one definition-that contribute to drug addiction, with the hope that such mechanistic insights may aid in the development of novel therapeutics for future treatments of addiction.

引用

页码：99 / 113

页数：15

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