Genomic Location Analysis by ChIP-Seq

被引：104

作者：

Barski, Artem ^{[1
]}

Zhao, Keji ^{[1
]}

机构：

[1] NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2009年 / 107卷 / 01期

关键词：

ChIP-Seq; CHROMATIN; TRANSCRIPTION FACTOR; FACTOR-BINDING-SITES; CHROMATIN IMMUNOPRECIPITATION; TRANSCRIPTION FACTORS; DNA INTERACTIONS; SERIAL ANALYSIS; WIDE ANALYSIS; STEM-CELLS; T-CELLS; IDENTIFICATION; PROMOTERS;

D O I：

10.1002/jcb.22077

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interaction of a multitude of transcription factors and other chromatin proteins with the genome can influence gene expression and subsequently cell differentiation and function. Thus systematic identification of binding targets of transcription factors is key to unraveling gene regulation networks. The recent development of ChIP-Seq has revolutionized mapping of DNA-protein interactions. Now protein binding can be mapped in a truly genome-wide manner with extremely high resolution. This review discusses ChIP-Seq technology, its possible pitfalls, data analysis and several early applications. J. Cell. Biochem. 107: 11-18, 2009. (C) 2009 Wiley-Liss, Inc.

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页码：11 / 18

页数：8

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