Evasion of innate and adaptive immune responses by influenza A virus

被引:76
作者
Schmolke, Mirco [1 ]
Garcia-Sastre, Adolfo [1 ,2 ,3 ]
机构
[1] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA
[2] Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA
[3] Mt Sinai Sch Med, Global Hlth & Emerging Pathogens Inst, New York, NY 10029 USA
关键词
NS1; PROTEIN; RIG-I; ANTIVIRAL RESPONSES; EPITHELIAL-CELLS; CUTTING EDGE; T-CELLS; RECEPTOR-BINDING; RECOGNITION; INFECTION; RNA;
D O I
10.1111/j.1462-5822.2010.01475.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
P>Host organisms have developed sophisticated antiviral responses in order to defeat emerging influenza A viruses (IAVs). At the same time IAVs have evolved immune evasion strategies. The immune system of mammals provides several lines of defence to neutralize invading pathogens or limit their replication. Here, we summarize the mammalian innate and adaptive immune mechanisms involved in host defence against viral infection and review strategies by which IAVs avoid, circumvent or subvert these mechanisms. We highlight well-characterized, as well as recently described features of this intriguing virus-host molecular battle.
引用
收藏
页码:873 / 880
页数:8
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