Quantum dots protected with tiopronin: A new fluorescence system for cell-biology studies

被引：36

作者：

de la Fuente, JM

Fandel, M

Berry, CC

Riehle, M

Cronin, L

Aitchison, G

Curtis, ASG

机构：

[1] Univ Glasgow, Ctr Cell Engn, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland

[2] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland

来源：

CHEMBIOCHEM | 2005年 / 6卷 / 06期

关键词：

bioorganic chemistry; nanotechnology; peptides; quantum dots; tiopronin;

D O I：

10.1002/cbic.200500071

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Water-soluble CdS nanocrystals functionalized with tiopronin have been developed by using a straightforward and economical methodology. These quantum dots are biocompatible with hTERT-BJ1 human fibroblasts. The functionalization of the quantum dots with a translocation peptide has allowed them to penetrate the cell membrane and target the nucleus (see scheme). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：989 / 991

页数：3