Human thioredoxin (TRX) was first identified in human T-cell leukemia virus type I (HTLV-I)-positive T-cell lines and is associated with the pathophysiology of retroviral infections. TRX is a vital component of the thiol-reducing system and regulates various cellular function ( redox regulation). Members of the TRX system regulate apoptosis through a wide variety of mechanisms. A family of thioredoxin-dependent peroxidases (peroxiredoxins) protects against apoptosis by scavenging hydrogen peroxide. Thioredoxin 2 is a critical regulator of cytochrome c release and mitochondrial apoptosis; transmembrane thioredoxin-related molecule (TMX) has a protective role in endoplasmic reticulum ( ER) stress-induced apoptosis. TRX interacts with apoptosis signal-regulating kinase 1 (ASK1) and is a sensor of oxidative stress. Thioredoxin binding protein-2/vitamin D-3 upregulated protein 1 is a growth suppressor and its expression is suppressed in HTLV-I-transformed cells. Studies of these molecules of the TRX system provide novel insights into the apoptosis associated with retroviral diseases.
机构:Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea
Han, SH
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Jeon, JH
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Ju, HR
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机构:Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea
Ju, HR
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Jung, U
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机构:Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea
Jung, U
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Kim, KY
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机构:Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea
Kim, KY
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Sook, H
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机构:Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea
Sook, H
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Yoo, HS
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Yoo, HS
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Lee, YH
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Song, KS
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Hwang, HM
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机构:Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea
Hwang, HM
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Na, YS
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机构:Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea
Na, YS
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Yang, Y
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机构:Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea
Yang, Y
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Lee, KN
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机构:Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea
Lee, KN
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Choi, I
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Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South KoreaKorea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea
机构:Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea
Han, SH
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Jeon, JH
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Ju, HR
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机构:Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea
Ju, HR
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Jung, U
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机构:Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea
Jung, U
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Kim, KY
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机构:Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea
Kim, KY
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Sook, H
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机构:Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea
Sook, H
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Yoo, HS
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Yoo, HS
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Lee, YH
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Song, KS
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Hwang, HM
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机构:Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea
Hwang, HM
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Na, YS
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机构:Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea
Na, YS
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Yang, Y
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机构:Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea
Yang, Y
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Lee, KN
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Lee, KN
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Choi, I
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Korea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South KoreaKorea Res Inst Biosci & Biotechnol, Immunol Lab, Taejon 305333, South Korea