The thioredoxin system in retroviral infection and apoptosis

被引:91
作者
Masutani, H
Ueda, S
Yodoi, J
机构
[1] Kyoto Univ, Inst Virus Res, Dept Biol Responses, Sakyo Ku, Kyoto 6068507, Japan
[2] Kyoto Univ Hosp, Translat Res Ctr, Dept Expt Therapeut, Thioredoxin Project,Sakyo Ku, Kyoto 606, Japan
关键词
thioredoxin; thioredoxin-binding protein-2 (TBP-2)/vitamin D-3 upregulated protein-1 (VDUP1); apoptosis; apoptosis signal-regulating kinase 1 (ASK1); HIV; HTLV-I;
D O I
10.1038/sj.cdd.4401625
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Human thioredoxin (TRX) was first identified in human T-cell leukemia virus type I (HTLV-I)-positive T-cell lines and is associated with the pathophysiology of retroviral infections. TRX is a vital component of the thiol-reducing system and regulates various cellular function ( redox regulation). Members of the TRX system regulate apoptosis through a wide variety of mechanisms. A family of thioredoxin-dependent peroxidases (peroxiredoxins) protects against apoptosis by scavenging hydrogen peroxide. Thioredoxin 2 is a critical regulator of cytochrome c release and mitochondrial apoptosis; transmembrane thioredoxin-related molecule (TMX) has a protective role in endoplasmic reticulum ( ER) stress-induced apoptosis. TRX interacts with apoptosis signal-regulating kinase 1 (ASK1) and is a sensor of oxidative stress. Thioredoxin binding protein-2/vitamin D-3 upregulated protein 1 is a growth suppressor and its expression is suppressed in HTLV-I-transformed cells. Studies of these molecules of the TRX system provide novel insights into the apoptosis associated with retroviral diseases.
引用
收藏
页码:991 / 998
页数:8
相关论文
共 93 条
[21]   The pathophysiology of mitochondrial cell death [J].
Green, DR ;
Kroemer, G .
SCIENCE, 2004, 305 (5684) :626-629
[22]   Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69 [J].
Haendeler, J ;
Hoffmann, J ;
Tischler, V ;
Berk, BC ;
Zeiher, AM ;
Dimmeler, S .
NATURE CELL BIOLOGY, 2002, 4 (10) :743-749
[23]   Dual regulation of caspase activity by hydrogen peroxide: Implications for apoptosis [J].
Hampton, MB ;
Orrenius, S .
FEBS LETTERS, 1997, 414 (03) :552-556
[24]   VDUP1 upregulated by TGF-β1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression [J].
Han, SH ;
Jeon, JH ;
Ju, HR ;
Jung, U ;
Kim, KY ;
Sook, H ;
Yoo, HS ;
Lee, YH ;
Song, KS ;
Hwang, HM ;
Na, YS ;
Yang, Y ;
Lee, KN ;
Choi, I .
ONCOGENE, 2003, 22 (26) :4035-4046
[25]   Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation [J].
Hatai, T ;
Matsuzawa, A ;
Inoshita, S ;
Mochida, Y ;
Kuroda, T ;
Sakamaki, K ;
Kuida, K ;
Yonehara, S ;
Ichijo, H ;
Takeda, K .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (34) :26576-26581
[26]   AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1 [J].
Hirota, K ;
Matsui, M ;
Iwata, S ;
Nishiyama, A ;
Mori, K ;
Yodoi, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) :3633-3638
[27]  
HOLMGREN A, 1995, METHOD ENZYMOL, V252, P199
[28]   Redox-active protein thioredoxin prevents proinflammatory cytokine- or bleomycin-induced lung injury [J].
Hoshino, T ;
Nakamura, H ;
Okamoto, M ;
Kato, S ;
Araya, S ;
Nomiyama, K ;
Oizumi, K ;
Young, HA ;
Aizawa, H ;
Yodoi, J .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2003, 168 (09) :1075-1083
[29]   Pancreatic β cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and Streptozotocin-induced diabetes [J].
Hotta, M ;
Tashiro, F ;
Ikegami, H ;
Niwa, H ;
Ogihara, T ;
Yodoi, J ;
Miyazaki, J .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (08) :1445-1451
[30]   Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways [J].
Ichijo, H ;
Nishida, E ;
Irie, K ;
tenDijke, P ;
Saitoh, M ;
Moriguchi, T ;
Takagi, M ;
Matsumoto, K ;
Miyazono, K ;
Gotoh, Y .
SCIENCE, 1997, 275 (5296) :90-94