Influence of weight loss on outcomes in patients with head and neck cancer undergoing concomitant chemoradiotherapy

被引：177

作者：

Capuano, Giorgio ^{[1
]}

Grosso, Alessandra ^{[1
]}

Gentile, Pier Carlo ^{[2
]}

Battista, Michele ^{[2
]}

Bianciardi, Federico ^{[2
]}

Di Palma, Annamaria ^{[2
]}

Pavese, Ida ^{[3
]}

Satta, Francesco ^{[3
]}

Tosti, Michela ^{[3
]}

Palladino, Anna ^{[3
]}

Coiro, Guido ^{[3
]}

Di Palma, Mario ^{[3
]}

机构：

[1] Osped San Pietro, Clin Nutr Unit, Rome, Italy

[2] Osped San Pietro, Radiotherapy Unit, Rome, Italy

[3] Osped San Pietro, Med Oncol Unit, Rome, Italy

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2008年 / 30卷 / 04期

关键词：

head and neck cancer; outcomes; morbidity; mortality; hospital readmission;

D O I：

10.1002/hed.20737

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. The purpose of this study was to determine the influence of weight loss on outcome in patients with head and neck cancer undergoing concomitant chemora-diotherapy (CCRT): treatment interruption, infections, mortality, and hospital readmission rate. Methods. Forty patients with head and neck cancer were enrolled. All patients were counseled to follow a nutritional program during CCRT. Body weight was evaluated at baseline, at the end, and 30 days after radiochemotherapy. Results. Ninety percent of compliant patients with nutritional program maintained body weight (mean, 1 +/- 2.4 kg) and 100 % of noncompliant patients continued to lose weight (mean, -9 +/- 4 kg; p <.001). A reduction greater than 20% of prediagnosis weight significantly correlated with treatment interruption (p =.003), infections (p =.002), early mortality (p =.011), hospital readmission rate (p =.001), and survival (log-rank test: z = -2.722, p =.006). Conclusion. In patients with head and neck cancer undergoing CCRT, the early nutritional management reduces weight loss and improve outcome. (C) 2007 Wiley Periodicals, Inc.

引用

页码：503 / 508

页数：6

共 29 条

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