MiR-25 regulates apoptosis by targeting Bim in human ovarian cancer

被引:205
作者
Zhang, Haiyan [1 ]
Zuo, Zhi [1 ]
Lu, Xin [1 ]
Wang, Li [1 ]
Wang, Haiyan [1 ]
Zhu, Zhiling [1 ]
机构
[1] Fudan Univ, Dept Gynecol, Obstet & Gynecol Hosp, Shanghai 200433, Peoples R China
关键词
ovarian cancer; miR-25; Bim; apoptosis; MICRORNA CLUSTER; GENE; EXPRESSION; MIRNAS; PCR;
D O I
10.3892/or.2011.1530
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
MicroRNAs (miRNAs) are emerging as a class of small regulatory RNAs whose alterations are implicated in the initiation and progression of human cancers. Our study showed that miR-25 was highly expressed both in clinical ovarian cancer samples and cell lines. Down-regulation of miR-25 in ovarian cancer cells induced apoptosis whereas overexpression of miR-25 enhanced cell proliferation. The effects of miR-25 abrogation were partly mediated by the intrinsic apoptosis pathway. Many pro-apoptotic proteins such as Bim, Bax and caspase-3 were up-regulated after transfection. Furthermore, luciferase assays demonstrated that Bim was the direct target of miR-25. Introducing Bim cDNA without 3'UTR abrogated miR-25-induced cell survival. Finally, there was an inverse relationship between Bim and miR-25 expression in ovarian cancer tissues. Taken together, these data indicate that miR-25 directly regulates apoptosis by targeting Bim in ovarian cancer and that miR-25 could be a potential therapeutic target for ovarian cancer intervention.
引用
收藏
页码:594 / 598
页数:5
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