Investigations on gossypol: past and present developments

被引：136

作者：

Dodou, K ^{[1
]}

机构：

[1] Univ Sunderland, Sch Pharm, Sunderland SR1 3SD, England

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2005年 / 14卷 / 11期

关键词：

antiapoptotic; anti-inflammatory; antimalarial; antioxidant; antiproliferative; antitumour; Bcl-xL; BH3; mimetic; enzyme inhibition; gossypol; gossypol derivatives; HIV-1; natural product; psoriasis;

D O I：

10.1517/13543784.14.11.1419

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Gossypol has received significant attention as a result of its potential therapeutic application as a male antifertility agent. Furthermore, recent research examining the biological activity of gossypol has revealed a number of other promising lines of enquiry. These have focused on the antitumour, antiviral and antioxidant actions of the compound in various disease states. This article provides an overview of the studies on the biological activity of gossypol, with particular attention paid to the mechanisms of its activity and its prospect as a medicinal product.

引用

页码：1419 / 1434

页数：16

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