A case of chronic pancreatic insufficiency due to valproic acid in a child

被引：6

作者：

Cooper, MA ^{[1
]}

Groll, A ^{[1
]}

机构：

[1] Univ Toronto, Hlth Sci Ctr, Sunnybrook & Womens Coll, Toronto, ON M4N 3M5, Canada

来源：

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2001年 / 15卷 / 02期

关键词：

chronic pancreatitis; pancreatic insufficiency; steatorrhea; valproic acid;

D O I：

10.1155/2001/687087

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A 14 -year-old child treated with valproic acid over several years for a seizure disorder developed abdominal pain with radiological evidence of acute pancreatitis. The association with valproic acid was not recognized, and the child continued to take the drug. The patient eventually developed steatorrhea and weight loss that improved with pancreatic enzyme replacement. Radiological evaluation showed an atrophic pancreas. Without evidence of other etiological factors, valproic acid by itself appeared to be the cause of chronic pancreatitis with exocrine pancreatic insufficiency in this patient.

引用

页码：127 / 130

页数：4

共 35 条

[11] PANCREATITIS IN CHILDREN ON CHRONIC DIALYSIS TREATED WITH VALPROIC ACID [J].

FORD, DM ;

PORTMAN, RJ ;

LUM, GM .

PEDIATRIC NEPHROLOGY, 1990, 4 (03) :259-261

[12] BIOCHEMICAL TESTS IN THE DIAGNOSIS OF CHRONIC-PANCREATITIS AND IN THE EVALUATION OF PANCREATIC INSUFFICIENCY [J].

GOLDBERG, DM ;

DURIE, PR .

CLINICAL BIOCHEMISTRY, 1993, 26 (04) :253-275

[13]

GRAM L, 1985, ACTA NEUROL SCAND, V72, P129

[14] PANCREATITIS IN CHILDREN AND ADOLESCENTS [J].

JORDAN, SC ;

AMENT, ME .

JOURNAL OF PEDIATRICS, 1977, 91 (02) :211-216

[15]

LOTT JA, 1990, CLIN CHEM, V36, P395

[16] Shwachman syndrome: Exocrine pancreatic dysfunction and variable phenotypic expression [J].

Mack, DR ;

Forstner, GG ;

Wilschanski, M ;

Freedman, MH ;

Durie, PR .

GASTROENTEROLOGY, 1996, 111 (06) :1593-1602

[17]

MURPHY MJ, 1981, LANCET, V1, P41

[18] ACUTE-PANCREATITIS AND SODIUM VALPROATE [J].

NG, JYK ;

DISNEY, APS ;

JONES, TE ;

PURDIE, G .

MEDICAL JOURNAL OF AUSTRALIA, 1982, 2 (08) :362-362

[19]

PARKER PH, 1981, GASTROENTEROLOGY, V80, P826

[20]

PEZZILLI R, 1991, ITAL J GASTROENTEROL, V23, P258

← 1 2 3 4 →