Hot flash severity in hormone therapy users/nonusers across the menopausal transition

被引:11
作者
Smith-DiJulio, Kathleen
Percival, Donald B.
Woods, Nancy Fugate
Tao, Eunice Y.
Mitchell, Ellen Sullivan
机构
[1] Univ Washington, Dept Child Nursing & Family, Seattle, WA 98195 USA
[2] Univ Washington, Appl Phys Lab, Seattle, WA 98195 USA
关键词
menopausal transition; menopause; postmenopause; hormone replacement therapy; hot flash severity;
D O I
10.1016/j.maturitas.2007.08.003
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objectives: The purpose of this study was to examine the pattern of and factors that influence hot flash severity across the menopausal transition (NIT) and early postmenopause (PM). Methods: Women from the Seattle Midlife Women's Health Study (N= 302) provided data for these analyses: at least one annual health questionnaire and a menstrual calendar. A subset of women provided a first morning voided urine specimen from 1997 through 2005. Urine samples were assayed for estrone glucuronide and FSH. Linear mixed effects modeling was used to identify change in hot flash severity scores over time, including the relationship to age, MT-related, psychosocial and lifestyle factors. Results: Increases in hot flash severity were associated with late transition stage, early postmenopause, use of HRT, duration of early transition stage, age of entry into early PM and level of FSH. Age of entry into early transition and estrone levels were associated with decreased hot flash severity. Not associated with hot flash severity were being in early transition stage, age of entry into or duration of late transition stage and all of the psychosocial (anxiety, stress, depressed mood) and lifestyle variables (BMI, activity level, sleep, alcohol use). Conclusions: Variables associated with reproductive aging independently predicted changes in hot flash severity; psychosocial and lifestyle variables did not. The effect of age dropped out when factors associated with reproductive aging were considered. Use of HRT ameliorated but did not eliminate severe hot flashes suggesting that there is room for alternative approaches less likely to cause harm. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:191 / 200
页数:10
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